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Trends Endocrinol Metab. 2015 May;26(5):248-55. doi: 10.1016/j.tem.2015.02.006. Epub 2015 Mar 21.

Notch signaling as a novel regulator of metabolism.

Author information

1
Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA. Electronic address: pbi@purdue.edu.
2
Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA; Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA. Electronic address: skuang@purdue.edu.

Abstract

Evolutionarily unprepared for modern high-calorie diets and sedentary lifestyles, humans are now unprecedentedly susceptible to metabolic disorders such as obesity, type 2 diabetes (T2D), nonalcoholic fatty liver, and cardiovascular disease. These metabolic conditions are intertwined, together known as metabolic syndrome, and compromise human life quality as well as lives. Notch signaling, a fundamental signal transduction pathway critical for cell-cell communication and development, has recently been recognized as a key player in metabolism. This review summarizes the emerging roles of Notch signaling in regulating the metabolism of various cell and tissue types, with emphasis on the underlying molecular mechanisms and the potential of targeting this signal axis to treat metabolic diseases.

KEYWORDS:

insulin resistance; notch signaling; obesity; type 2 diabetes

PMID:
25805408
PMCID:
PMC4435535
DOI:
10.1016/j.tem.2015.02.006
[Indexed for MEDLINE]
Free PMC Article

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