Concentration, distribution, probable sources, and health risks of 16 polycyclic aromatic hydrocarbons (PAHs) were investigated in 52 soil samples collected within a radius 50 km from Isfahan metropolis center. Total concentration of PAHs ranged from 57.70 to 11,730.08 μg/kg averaging 2,000.56 μg/kg. Spatial PAH profiles were site-specific and higher concentration of PAHs was observed in the vicinity of industrial zones within Isfahan metropolis. The molecular indices, ring classes, and principal component analysis indicated that the sources of PAHs were both geogenic and pyrogenic. The incremental lifetime cancer risks of exposure to soil PAHs for adults and children living in the study area were 2.3×10(-2) and 2.2×10(-3), respectively. The results suggest that current PAHs levels in Isfahan metropolis soil are highly carcinogenic and may hold a serious health risk for local resident.