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Nanoscale. 2015 Apr 21;7(15):6754-61. doi: 10.1039/c5nr01055a.

Dye-free near-infrared surface-enhanced Raman scattering nanoprobes for bioimaging and high-performance photothermal cancer therapy.

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MOE Key Laboratory of Laser Life Science & SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology, College of Biophotonics, South China Normal University, Guangzhou, Guangdong 510631, PR China.


Near-infrared surface-enhanced Raman scattering (NIR SERS) imaging is now a promising molecular imaging technology due to its narrow spectral bandwidth, low background interference and deep imaging depth. In this work, we report a novel strategy for fabrication of NIR SERS nanoprobes without using any expensive and highly toxic organic dyes. Multifunctional conducting polymer (CP) materials, serving as both biocompatible surface coatings and NIR-active reporters, are directly fabricated on the surface of gold nanorods (GNRs) via facile oxidative polymerization. The dye-free NIR SERS nanoprobes (GNR-CPs) exhibit good structural stability, good biocompatibility and intriguing NIR SERS activity. GNR-CPs also show an extraordinary NIR photothermal transduction efficiency, indicating the potential for cancer therapy. The applications of GNR-CPs as new types of theranostic agents for NIR SERS imaging and high-performance photothermal therapy are accomplished in vitro and in vivo.

[Indexed for MEDLINE]

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