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Eur J Clin Nutr. 2015 Aug;69(8):969-71. doi: 10.1038/ejcn.2015.28. Epub 2015 Mar 25.

Omega-3 fatty acids in the management of autism spectrum disorders: findings from an open-label pilot study in Singapore.

Author information

1
1] Clinical Psychology and Psychotherapy, Department of Psychology, University of Basel, Basel, Switzerland [2] Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore [3] Child Guidance Clinic, 3 Second Hospital Avenue, Health Promotion Board, Singapore, Singapore.
2
1] Child Guidance Clinic, 3 Second Hospital Avenue, Health Promotion Board, Singapore, Singapore [2] DUKE-NUS Graduate Medical School Singapore, Singapore, Singapore.
3
Child Guidance Clinic, 3 Second Hospital Avenue, Health Promotion Board, Singapore, Singapore.
4
National Institute of Education, Nanyang Technological University, Singapore, Singapore.
5
1] Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore [2] Child Guidance Clinic, 3 Second Hospital Avenue, Health Promotion Board, Singapore, Singapore [3] DUKE-NUS Graduate Medical School Singapore, Singapore, Singapore.

Abstract

The goal of this open-label trial was to examine the efficacy and safety of a 12-week omega-3 fatty acids supplementation among children suffering with Autism Spectrum Disorders (ASD). A total of 41 children and adolescents aged 7-18 years (36 boys, 5 girls; mean age = 11.66, s.d. = 3.05) diagnosed with ASD participated in the study. At post-treatment, participants showed significant improvements on all subscales of the Social Responsiveness Scale (P < 0.01) and the Social and Attention Problems syndrome scales of the Child Behavior Checklist (P < 0.05). Blood fatty acid levels were significantly correlated with changes in the core symptoms of ASD. Baseline levels of blood fatty acid levels were also predictive of response to the omega-3 treatment. Omega-3 fatty acids supplementation was well-tolerated and did not cause any serious side effects. Our findings lend some preliminary support for the use of omega-3 fatty acids supplementation in addressing ASD. Future randomized controlled trials of omega-3 fatty acids in ASD with blood fatty acid measurements with a larger sample and longer follow-up period is warranted.

PMID:
25804268
DOI:
10.1038/ejcn.2015.28
[Indexed for MEDLINE]

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