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Nat Commun. 2015 Mar 24;6:6596. doi: 10.1038/ncomms7596.

Unravelling the hidden ancestry of American admixed populations.

Author information

1
1] Institute of Legal Medicine, Catholic University, Largo F. Vito 1, Rome 00168, Italy [2] Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.
2
1] Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK [2] Wellcome Trust Center for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.
3
Institute of Legal Medicine, Catholic University, Largo F. Vito 1, Rome 00168, Italy.
4
1] Wellcome Trust Center for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK [2] Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK.
5
UCL Genetics Institute, University College London, WC1E 6BT Gower Street, UK.
6
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.

Abstract

The movement of people into the Americas has brought different populations into contact, and contemporary American genomes are the product of a range of complex admixture events. Here we apply a haplotype-based ancestry identification approach to a large set of genome-wide SNP data from a variety of American, European and African populations to determine the contributions of different ancestral populations to the Americas. Our results provide a fine-scale characterization of the source populations, identify a series of novel, previously unreported contributions from Africa and Europe and highlight geohistorical structure in the ancestry of American admixed populations.

PMID:
25803618
PMCID:
PMC4374169
DOI:
10.1038/ncomms7596
[Indexed for MEDLINE]
Free PMC Article
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