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Cytotherapy. 2015 Jun;17(6):775-785. doi: 10.1016/j.jcyt.2015.03.004. Epub 2015 Mar 19.

Cord blood for brain injury.

Author information

1
Pediatric Blood and Marrow Transplant Program, Duke University, Durham, North Carolina, USA; The Robertston Clinical and Translational Cell Therapy Program, Duke University, Durham, North Carolina, USA. Electronic address: jessica.sun@duke.edu.
2
Pediatric Blood and Marrow Transplant Program, Duke University, Durham, North Carolina, USA; The Robertston Clinical and Translational Cell Therapy Program, Duke University, Durham, North Carolina, USA; The Carolinas Cord Blood Bank, Durham, North Carolina, USA.

Abstract

Recovery from neurological injuries is typically incomplete and often results in significant and permanent disabilities. Currently, most available therapies are limited to supportive or palliative measures, aimed at managing the symptoms of the condition. Because restorative therapies targeting the underlying cause of most neurological diseases do not exist, cell therapies targeting anti-inflammatory, neuroprotective and regenerative potential hold great promise. Cord blood (CB) cells can induce repair through mechanisms that involve trophic or cell-based paracrine effects or cellular integration and differentiation. Both may be operative in emerging CB therapies for neurologic conditions, and there are numerous potential applications of CB-based regenerative therapies in neurological diseases, including genetic diseases of childhood, ischemic events such as stroke and neurodegenerative diseases of adulthood. CB appears to hold promise as an effective therapy for patients with brain injuries. In this Review, we describe the state of science and clinical applications of CB therapy for brain injury.

KEYWORDS:

brain injury; cell therapy; regenerative medicine; umbilical cord blood

PMID:
25800775
DOI:
10.1016/j.jcyt.2015.03.004
[Indexed for MEDLINE]

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