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Cell. 2015 Apr 9;161(2):374-86. doi: 10.1016/j.cell.2015.01.056. Epub 2015 Mar 19.

Actin flows mediate a universal coupling between cell speed and cell persistence.

Author information

1
Institut Curie, CNRS UMR 144, 26 rue d'Ulm, 75005 Paris, France.
2
Laboratoire de Physique Théorique de la Matière Condensée, UMR 7600 CNRS /UPMC, 4 Place Jussieu, 75255 Paris Cedex, France.
3
Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria.
4
Institut Curie, CNRS UMR 168, 26 rue d'Ulm, 75005 Paris, France.
5
Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel.
6
Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, 20132 Milan, Italy.
7
U 653, Inserm/Institut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France.
8
Institut Curie, CNRS UMR 144, 26 rue d'Ulm, 75005 Paris, France. Electronic address: matthieu.piel@curie.fr.
9
Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria. Electronic address: sixt@ist.ac.at.
10
Laboratoire de Physique Théorique de la Matière Condensée, UMR 7600 CNRS /UPMC, 4 Place Jussieu, 75255 Paris Cedex, France; Laboratoire Jean Perrin, UMR 8237 CNRS /UPMC, 4 Place Jussieu, 75255 Paris Cedex, France. Electronic address: voiturie@lptmc.jussieu.fr.

Abstract

Cell movement has essential functions in development, immunity, and cancer. Various cell migration patterns have been reported, but no general rule has emerged so far. Here, we show on the basis of experimental data in vitro and in vivo that cell persistence, which quantifies the straightness of trajectories, is robustly coupled to cell migration speed. We suggest that this universal coupling constitutes a generic law of cell migration, which originates in the advection of polarity cues by an actin cytoskeleton undergoing flows at the cellular scale. Our analysis relies on a theoretical model that we validate by measuring the persistence of cells upon modulation of actin flow speeds and upon optogenetic manipulation of the binding of an actin regulator to actin filaments. Beyond the quantitative prediction of the coupling, the model yields a generic phase diagram of cellular trajectories, which recapitulates the full range of observed migration patterns.

PMID:
25799384
DOI:
10.1016/j.cell.2015.01.056
[Indexed for MEDLINE]
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