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Bone Marrow Transplant. 2015 Jun;50(6):781-9. doi: 10.1038/bmt.2015.52. Epub 2015 Mar 23.

Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives-a position statement from the European Society for Blood and Marrow Transplantation (EBMT).

Author information

1
Hematology department, Hôpital Saint-Antoine, and Université Pierre & Marie Curie, Paris, France.
2
Inst Portugues Oncologia, Lisboa, Portugal.
3
Department of Haematology, University Hospital Zurich, Zurich, Switzerland.
4
King Abdullah International Medical Research Center/King Saud Bin Abdulaziz University for Health Sciences, Department of Oncology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
5
King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
6
Sisli Florence Nightingale Hospital, HSCT Unit, Istanbul, Turkey.
7
Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University, Frankfurt/Main, Germany.
8
Department of Hematology, University of Liege, Liege, Belgium.
9
Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.
10
Blood and Marrow Transplantation Program, Hematology Department, Institut Paoli-Calmettes, Marseille, France.
11
Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy.
12
Department of Hematology, Oncology, and Stem Cell Transplantation, University of Regensburg, Regensburg, Germany.
13
Department of Hematology and Immunology, Hospital Robert Debre, Paris 7-Paris Diderot University, Paris, France.
14
Department of Haematology, Institut Català d'Oncología (ICO) - Hospital Duran i Reynals, Hospitalet de Llobregat, Barcelona, Spain.
15
HSCT division, National Cancer Center Hospital, Tokyo, Japan.
16
Hematology department, Institut Universitaire du Cancer Toulouse - Oncopole, Toulouse, France.
17
Department of Hematology and Stem Cell Transplantation, St. Istvan and St. Laszlo Hospital, Budapest 3 Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
18
Hematology Department, Groupement Hospitalier Sud, Hospices Civils de Lyon, Université Claude Bernard Lyon EST, Pierre Bénite, France.
19
Hematology and Bone Marrow Transplantation, Chaim Sheba Medical center, Tel-Hashomer, Israel.
20
National Stem Cell Transplant Unit (Adults), Department of Haematology, St James's Hospital and Academic Department of Haematology, Trinity College Dublin, Dublin, Ireland.
21
Department of Haematology, King's College Hospital, London, UK.
22
Department of Pediatrics, St. Anna Kinderspital, Vienna, Austria.
23
LDS Hospital, Salt Lake City, UT, USA.
24
Division of Hematologic Malignancy, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
25
Comprehensive Cancer Center, Helsinki University Central Hospital, Helsinki, Finland.
26
Hematology and Stem Cell Transplantation Section, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center and Veterans Affairs Medical Center, Nashville, TN, USA.
27
Section of Haematology and Coagulation, Department of Internal Medicine, Sahlgrenska University Hospital, Göteborg, Sweden.
28
Bone Marrow Transplantation Unit, CHU de Lille, Lille, France.
29
1] Josep Carreras Leukaemia Research Institute, Barcelona, Spain [2] Haematology Department, Hospital Clinic, Barcelona, Spain [3] Spanish Bone Marrow Donor Program, Josep Carreras Foundation, Barcelona, Spain.

Abstract

Sinusoidal obstruction syndrome or veno-occlusive disease (SOS/VOD) is a potentially life-threatening complication of hematopoietic SCT (HSCT). This review aims to highlight, on behalf of the European Society for Blood and Marrow Transplantation, the current knowledge on SOS/VOD pathophysiology, risk factors, diagnosis and treatments. Our perspectives on SOS/VOD are (i) to accurately identify its risk factors; (ii) to define new criteria for its diagnosis; (iii) to search for SOS/VOD biomarkers and (iv) to propose prospective studies evaluating SOS/VOD prevention and treatment in adults and children.

PMID:
25798682
PMCID:
PMC4456788
DOI:
10.1038/bmt.2015.52
[Indexed for MEDLINE]
Free PMC Article

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