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Comput Med Imaging Graph. 2015 Jul;43:36-43. doi: 10.1016/j.compmedimag.2015.02.010. Epub 2015 Mar 7.

Texture analysis and classification in coherent anti-Stokes Raman scattering (CARS) microscopy images for automated detection of skin cancer.

Author information

1
Abbe School of Photonics, Friedrich-Schiller University Jena, Germany; Leibniz-Institute of Photonic Technology (IPHT) Jena e.v., Albert-Einstein-Str. 9, 07745 Jena, Germany.
2
Leibniz-Institute of Photonic Technology (IPHT) Jena e.v., Albert-Einstein-Str. 9, 07745 Jena, Germany.
3
Leibniz-Institute of Photonic Technology (IPHT) Jena e.v., Albert-Einstein-Str. 9, 07745 Jena, Germany; Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich-Schiller University Jena, Helmholtzweg 4, 07743 Jena, Germany. Electronic address: juergen.popp@ipht-jena.de.

Abstract

Coherent anti-Stokes Raman scattering (CARS) microscopy is a powerful tool for fast label-free tissue imaging, which is promising for early medical diagnostics. To facilitate the diagnostic process, automatic image analysis algorithms, which are capable of extracting relevant features from the image content, are needed. In this contribution we perform an automated classification of healthy and tumor areas in CARS images of basal cell carcinoma (BCC) skin samples. The classification is based on extraction of texture features from image regions and subsequent classification of these regions into healthy and cancerous with a perceptron algorithm. The developed approach is capable of an accurate classification of texture types with high sensitivity and specificity, which is an important step towards an automated tumor detection procedure.

KEYWORDS:

CARS; Image analysis; Perceptron algorithm; Texture analysis

[Indexed for MEDLINE]

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