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J Laryngol Otol. 2015 Mar;129(3):206-11. doi: 10.1017/S0022215114003478.

Facial transplantation: historical developments and future directions.

Author information

1
ENT Department, Lewisham Health Care NHS Trust,London,UK.
2
ENT Department, Royal Free London NHS Foundation Trust,UK.

Abstract

OBJECTIVE:

To present the clinical outcomes obtained by the first facial transplant teams worldwide, reviewing current practice and addressing controversies.

METHODS:

A bibliographic search of Medline and Embase databases was performed, and a comparative analysis of all articles published from 1980 to the present was conducted. Two independent investigators screened the manuscripts in accordance with pre-defined criteria.

RESULTS:

A total of 12 partial and 5 full facial transplants were recorded in the literature. Procedures included partial and near-total facial myocutaneous flaps, and complex osteomyocutaneous grafts. Fifteen patients had fully vascularised grafts, and two patients died of transplant-related and infectious complications.

CONCLUSION:

Facial transplantation can restore quality of life and enable the social re-integration of recipients. Results published by the first facial transplant teams are promising. However, long-term reports of aesthetic and functional outcomes are needed to more precisely define outcomes. In addition, significant technical, medical and ethical issues remain to be solved.

KEYWORDS:

Composite Tissue Allografts

PMID:
25797446
DOI:
10.1017/S0022215114003478
[Indexed for MEDLINE]

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