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Brain Res. 1985 Jan 28;325(1-2):294-8.

Evidence that substance P and somatostatin transmit separate information related to pain in the spinal dorsal horn.

Abstract

Effects of various types of natural skin stimuli on the in situ release of immunoreactive substance P and somatostatin from the rabbit dorsal horn were examined. Noxious mechanical or thermal stimuli specifically increased the release of immunoreactive substance P or somatostatin, respectively. Innocuous stimuli did not affect the release of these peptides. These results suggest that the nociceptive mechanical or thermal primary afferents contain substance P or somatostatin, respectively.

PMID:
2579706
DOI:
10.1016/0006-8993(85)90326-9
[Indexed for MEDLINE]

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