Format

Send to

Choose Destination
Environ Int. 2015 May;78:90-94. doi: 10.1016/j.envint.2015.02.004. Epub 2015 Mar 18.

Prenatal and early-life polychlorinated biphenyl (PCB) levels and behavior in Inuit preschoolers.

Author information

1
Department of Environmental Health, Harvard School of Public Health, 401 Park Drive, HSPH-BWH-301W, Boston, MA 02215, USA; Institute of Environmental Medicine, Karolinska Institutet, Box 210, Nobelsväg 13, Solna 171 77, Sweden. Electronic address: remav@channing.harvard.edu.
2
Centre for Studies on Human Stress, Research Center of the Mental Health Institute, 7401 Rue Hochelaga, Montreal, Quebec, H1N 3M5, Canada; Etholabs, School of Psychoeducation, University of Montreal, C. P. 6128, succursale Centre-ville, Montreal, Quebec, H3C 3J7, Canada. Electronic address: pierrich.plusquellec@umontreal.ca.
3
Centre for Studies on Human Stress, Research Center of the Mental Health Institute, 7401 Rue Hochelaga, Montreal, Quebec, H1N 3M5, Canada. Electronic address: justine.desjardins@gmail.com.
4
Département de psychologie, Université du Québec à Montréal, 320 Sainte-Catherine Est Pavillon J.A. De Sève, local DS5775, Montreal, Quebec H2X 1L7, Canada; INSERM U1085, Université Rennes I, 263 Avenue du Général Leclerc, 35042 Rennes, France. Electronic address: cartier.chloe@gmail.com.
5
Department of Occupational and Environmental Health, School of Public Health, Université de Montréal, 2375 ch. de la Cote-Sainte-Catherine, Montreal, Quebec, H3T 1A8, Canada; Université de Montréal Public Health Research Institute, Université de Montréal, 7101 avenue du Parc, office 3187-03, Montreal, Quebec, H3N 1X9, Canada. Electronic address: sami.haddad@umontreal.ca.
6
Centre de recherche du CHU de Québec, Université Laval, 2875 Laurier, Quebec, Quebec G1V 2M2, Canada. Electronic address: pierre.ayotte@crchul.ulaval.ca.
7
Centre de recherche du CHU de Québec, Université Laval, 2875 Laurier, Quebec, Quebec G1V 2M2, Canada. Electronic address: eric.dewailly@crchul.ulaval.ca.
8
Centre de recherche du CHU de Québec, Université Laval, 2875 Laurier, Quebec, Quebec G1V 2M2, Canada. Electronic address: gina.muckle@psy.ulaval.ca.

Abstract

BACKGROUND:

Whereas it is well established that prenatal exposure to polychlorinated biphenyls (PCBs) can disrupt children's behavior, early postnatal exposure has received relatively little attention in environmental epidemiology.

OBJECTIVES:

To evaluate prenatal and postnatal exposures to PCB-153, a proxy of total PCB exposure, and their relation to inattention and activity in 5-year-old Inuits from the Cord Blood Monitoring Program.

METHODS:

Prenatal exposure to PCBs was informed by cord plasma PCB-153 levels. We used a validated pharmacokinetic model to estimate monthly infants' levels across the first year of life. Inattention and activity were assessed by coding of video recordings of children undergoing fine motor testing. We used multivariable linear regression to evaluate the association between prenatal and postnatal PCB-153 levels and inattention (n=97) and activity (n=98) at 5years of age.

RESULTS:

Cord plasma PCB-153 was not associated with inattention and activity. Each interquartile range (IQR) increase in estimated infant PCB-153 levels at 2months was associated with a 1.02% increase in the duration of inattention (95% CI: 0.04, 2.00). Statistical adjustment for the duration of breastfeeding slightly increased regression coefficients for postnatal level estimates, some of which became statistically significant for inattention (months: 2-4) and activity (months: 2-5).

CONCLUSIONS:

Our study adds to the growing evidence of postnatal windows of development during which children are more susceptible to neurotoxicants like PCBs.

KEYWORDS:

Behavior; Pharmacokinetic modeling; Polychlorinated biphenyls (PCBs); Postnatal exposure; Preschoolers

PMID:
25796081
DOI:
10.1016/j.envint.2015.02.004
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science Icon for Corpus, Universite Laval
Loading ...
Support Center