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Nutr Hosp. 2015 Apr 1;31(4):1633-40. doi: 10.3305/nh.2015.31.4.8448.

[Prevalence of vitamin d deficiency and insuffiency and associated factors in pregnant women of northern Spain].

[Article in Spanish; Abstract available in Spanish from the publisher]

Author information

Servicio de Pediatría, Hospital San Agustín, Avilés, Asturias..
Servicio de Pediatría, Hospital San Agustín, Avilés, Asturias. CIBER en Epidemiología y Salud Pública (CIBERESP)..
Servicio de Medicina Preventiva, Universidad de Oviedo, Asturias. CIBER en Epidemiología y Salud Pública (CIBERESP)..
CIBER en Epidemiología y Salud Pública (CIBERESP). Departamento de Salud Pública, Universidad Miguel Hernández, Elche, Alicante..
Unidad de Química Clínica, Salud Pública Laboratorio de Bilbao, Euskadi. España..


in English, Spanish


The vitamin D deficiency during pregnancy has been associated with adverse events during pregnancy and the postnatal child development. In this study we examined plasma levels of vitamin D [25(OH)D3] and factors associated with plasma deficiency and insufficiency in pregnant women in northern Spain.


We analyzed data from 453 pregnant women participating in the INMA-Asturias cohort in which was determined 25(OH)D3 by high resolution liquid chromatography.Dietary intake of vitamin D was estimated through a food frequency validated questionnaire. We estimated the prevalence of deficiency [25(OH)D3 <20 ng/ml] and insufficiency [20 to 29.9 ng / ml] of vitamin D and analyzed the distribution of 25(OH)D3 per month extraction and other factors.


The mean concentration of 25(OH)D3 was 27.7 ng/ml (range 6.4 to 69.5). 27.4% of pregnant women had deficient levels and 35.3% inssuficient. Levels of 25(OH)D3 were higher in the summer months (median 34.1 ng/ml). There was a higher percentage of deficiency in pregnant women with overweight/obesity (34.5%) and under 25 years (47.8%). The average daily intake of vitamin D was 5.48 mg / day (SD 2.82 range 1.09 to 32.52).Intake during the months of October to May was associated with levels of 25(OH)D3. 8.6% reported taking supplements of vitamin D.


We detected a high proportion of pregnant women with deficient or insufficient vitamin D levels, especially in the months of October to May, in pregnant women with overweight and obesity, and the youngest.

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