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BMJ Open. 2015 Mar 20;5(3):e006897. doi: 10.1136/bmjopen-2014-006897.

Nutrition and dietary intake and their association with mortality and hospitalisation in adults with chronic kidney disease treated with haemodialysis: protocol for DIET-HD, a prospective multinational cohort study.

Collaborators (283)

Raña S, Serrano M, Claros S, Arias M, Petracci L, Arana M, De Rosa P, Gutierrez A, Simon M, Vergara V, Tosi M, Cernadas M, Vilamajó I, Gravac D, Paulón M, Penayo L, Carrizo G, Ghiani M, Perez G, Da Cruz O, Galarce D, Gravielle M, Vescovo E, Paparone R, Mato Mira C, Mojico E, Hermida O, Florio D, Yucoswky M, Labonia W, Rubio D, Di Napoli G, Fernandez A, Altman H, Rodriguez J, Serrano S, Valle G, Lobos M, Acosta V, Corpacci G, Jofre M, Gianoni L, Chiesura G, Capdevila M, Montenegro J, Bequi J, Dayer J, Gómez A, Calderón C, Abrego E, Cechín C, García J, Corral J, Natiello M, Coronel A, Muñiz M, Muñiz V, Bonelli A, Sanchez F, Maestre S, Olivera S, Camargo M, Avalos V, Geandet E, Canteli M, Escobar A, Sena E, Tirado S, Peñalba A, Neme G, Cisneros M, Oliszewski R, Nascar V, Daud M, Mansilla S, Paredes Álvarez A, Gamín L, Arijón M, Coombes M, Zapata M, Boriceanu C, Lankester M, Poignet JL, Saingra Y, Indreies M, Santini J, Amar M, Robert A, Bouvier P, Merzouk T, Villemain F, Pajot A, Tollis F, Brahim-Bounab M, Benmoussa A, Albitar S, Guimont MC, Ciobotaru P, Guerin A, Diaconita M, SHH, Saupe J, Ullmann I, Grosser S, Kunow J, Grueger S, Bischoff D, Benders J, Worch P, Pfab T, Kamin N, Roesch M, Albert K, Csaszar I, Kiss E, Kosa D, Orosz A, Redl J, Kovacs L, Varga E, Szabo M, Magyar K, Zajko E, Bereczki A, Csikos J, Kerekes E, Mike A, Steiner K, Nemeth E, Tolnai K, Toth A, Vinczene J, Szummer S, Tanyi E, Szilvia M, Murgo AM, Sanfilippo N, Dambrosio N, Saturno C, Matera G, Benevento M, Greco V, di Leo G, Papagni S, Alicino F, Marangelli A, Pedone F, Cagnazzo AV, Antinoro R, Sambati ML, Donatelli C, Ranieri F, Torsello F, Steri P, Riccardi C, Flammini A, Moscardelli L, Boccia E, Mantuano M, Di Toro Mammarella R, Meconizzi M, Fichera R, D'Angelo A, Latassa G, Molino A, Fici M, Lupo A, Montalto G, Messina S, Capostagno C, Randazzo G, Pagano S, Marino G, Rallo D, Maniscalco A, Trovato OM, Strano C, Failla A, Bua A, Campo S, Nasisi P, Salerno A, Laudani S, Grippaldi F, Bertino D, Di Benedetto DV, Puglisi A, Chiarenza S, Lentini Deuscit M, Incardona CM, Scuto G, Todaro C, Dino A, Novello D, Coco A, Bocheńska-Nowacka E, Jaroszyński A, Drabik J, Wypych-Birecka M, Daniewska D, Drobisz M, Doskocz K, Wyrwicz-Zielińska G, Kosicki A, Ślizień WS, Rutkowski P, Arentowicz S, Dzimira S, Grabowska M, Ostrowski J, Całka A, Grzegorczyk T, Dżugan W, Mazur M, Myślicki M, Piechowska M, Kozicka D, Mira AR, Martins V, Velez B, Pinheiro T, Agapi E, Ardelean CL, Baidog A, Bako G, Barb M, Blaga A, Bodurian E, Bumbea V, Dragan E, Dumitrache D, Florescu L, Havasi N, Hint S, Ilies R, Mandita AG, Marian RI, Medrihan SL, Mitea L, Mitea S, Mocanu R, Moro DC, Nitu M, Popa ML, Popa M, Railean E, Scuturdean AR, Szentendrey K, Teodoru CL, Varga A, Bernat A, De la Torre B, Lopez A, Martin J, Cuesta G, Rodriguez RM, Ros F, Garcia M, Orero E, Ros E, Fabricius E, Goch J, Katzarski KS, Wulcan A, Akbiber H, Arslan H, Bicen L, Buyukkiraz A, Celik R, Dogan IS, Erkalkan S, Ertas A, Hark U, Iravul E, Karakaya M, Mengu K, Ongun S, Ozkan Z, Ozlu A, Ozveren N, Sifil HM, Sonmez Turksoz N, Yilmaz Z.

Author information

1
Department of Medicine, University of Otago Christchurch, Christchurch, New Zealand.
2
Diaverum Medical Scientific Office, Lund, Sweden Division of Nephrology and Transplantation, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.
3
Department of Nutrition and Dietetics, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
4
Faculty of Medicine, National Health and Lung Institute, Imperial College of Science, Technology, and Medicine, Royal Brompton campus, London, UK.
5
Diaverum Medical Scientific Office, Lund, Sweden.
6
Sydney School of Public Health, Edward Ford Building, University of Sydney, Sydney, New South Wales, Australia.
7
Department of Nephrology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
8
Cumming School of Medicine, University of Calgary, 2500 University Drive Northwest, Calgary, Alberta, Canada.
9
The George Institute for Global Health, Sydney, New South Wales, Australia.
10
Diaverum Medical Scientific Office, Lund, Sweden Department of Nephrology, Medical University of Lublin, Lublin, Poland.
11
Diaverum Medical Scientific Office, Lund, Sweden Department of Internal Medicine, Metabolic Diseases, Medical University of Silesia, Katowice, Poland.
12
Diaverum Medical Scientific Office, Lund, Sweden Nephrology and Infectiology Research and Development Group, INEB, and School of Medicine, Porto University, Porto, Portugal.
13
Diaverum Medical Scientific Office, Lund, Sweden Sydney School of Public Health, Edward Ford Building, University of Sydney, Sydney, New South Wales, Australia Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy Diaverum Academy, Bari, Italy.

Abstract

INTRODUCTION:

Adults with end-stage kidney disease (ESKD) treated with haemodialysis experience mortality of between 15% and 20% each year. Effective interventions that improve health outcomes for long-term dialysis patients remain unproven. Novel and testable determinants of health in dialysis are needed. Nutrition and dietary patterns are potential factors influencing health in other health settings that warrant exploration in multinational studies in men and women treated with dialysis. We report the protocol of the "DIETary intake, death and hospitalisation in adults with end-stage kidney disease treated with HaemoDialysis (DIET-HD) study," a multinational prospective cohort study. DIET-HD will describe associations of nutrition and dietary patterns with major health outcomes for adults treated with dialysis in several countries.

METHODS AND ANALYSIS:

DIET-HD will recruit approximately 10,000 adults who have ESKD treated by clinics administered by a single dialysis provider in Argentina, France, Germany, Hungary, Italy, Poland, Portugal, Romania, Spain, Sweden and Turkey. Recruitment will take place between March 2014 and June 2015. The study has currently recruited 8000 participants who have completed baseline data. Nutritional intake and dietary patterns will be measured using the Global Allergy and Asthma European Network (GA(2)LEN) food frequency questionnaire. The primary dietary exposures will be n-3 and n-6 polyunsaturated fatty acid consumption. The primary outcome will be cardiovascular mortality and secondary outcomes will be all-cause mortality, infection-related mortality and hospitalisation.

ETHICS AND DISSEMINATION:

The study is approved by the relevant Ethics Committees in participating countries. All participants will provide written informed consent and be free to withdraw their data at any time. The findings of the study will be disseminated through peer-reviewed journals, conference presentations and to participants via regular newsletters. We expect that the DIET-HD study will inform large pragmatic trials of nutrition or dietary interventions in the setting of advanced kidney disease.

KEYWORDS:

EPIDEMIOLOGY; NUTRITION & DIETETICS

PMID:
25795691
PMCID:
PMC4368922
DOI:
10.1136/bmjopen-2014-006897
[Indexed for MEDLINE]
Free PMC Article

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