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Am J Ophthalmol. 2015 Jun;159(6):1152-1160.e2. doi: 10.1016/j.ajo.2015.03.008. Epub 2015 Mar 17.

P-selectin Plasma Levels and Genetic Variant Associated With Diabetic Retinopathy in African Americans.

Author information

1
Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, Mississippi.
2
Department of Ophthalmology, University of Mississippi Medical Center, Jackson, Mississippi.
3
Department of Physiology and Biophysics, University of Mississippi, Jackson, Mississippi.
4
Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
5
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts. Electronic address: lucia_sobrin@meei.harvard.edu.

Abstract

PURPOSE:

To report the prevalence and risk factors for retinopathy in African Americans with impaired fasting glucose (IFG) and type 2 diabetes in the Jackson Heart Study and to determine if P-selectin plasma levels are independently associated with retinopathy in this population.

DESIGN:

Prospective, cross-sectional observational study.

METHODS:

setting: Community-based epidemiologic study.

STUDY POPULATION:

Total of 629 patients with type 2 diabetes and 266 participants with impaired fasting glucose.

OBSERVATION PROCEDURES:

Bilateral, 7-field fundus photographs were scored by masked readers for diabetic retinopathy (DR) level. Covariate data including P-selectin plasma levels and genotypes were collected in a standardized fashion.

MAIN OUTCOME MEASURES:

Association between risk factors, including P-selectin plasma levels and genotypes, and retinopathy.

RESULTS:

The prevalences of any retinopathy among participants with IFG and type 2 diabetes were 9.4% and 32.4%, respectively. Among those with type 2 diabetes, in multivariate models adjusted for age, sex, and other traditional risk factors, higher P-selectin levels were associated with any DR (odds ratio = 1.11, 95% confidence interval = 1.02-1.21, P = .02) and proliferative DR (odds ratio = 1.23, 95% confidence interval = 1.03-1.46, P = .02). To further investigate the relationship between P-selectin and DR, we examined the association between P-selectin genotype and DR. Minor allele homozygotes for the variant rs6128 were less likely to develop DR (P after Bonferroni correction = 0.03).

CONCLUSIONS:

Both serologic and genetic data show an association between P-selectin and DR in the Jackson Heart Study. If confirmed in other studies, this association may provide insight into the pathogenesis of retinopathy.

PMID:
25794792
PMCID:
PMC4426234
DOI:
10.1016/j.ajo.2015.03.008
[Indexed for MEDLINE]
Free PMC Article

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