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Eur J Pharm Biopharm. 2015 Jun;93:37-45. doi: 10.1016/j.ejpb.2015.03.005. Epub 2015 Mar 17.

Curcumin loaded PLGA-poloxamer blend nanoparticles induce cell cycle arrest in mesothelioma cells.

Author information

1
Dipartimento di Farmacia, Università di Napoli Federico II, Via D. Montesano 49, Napoli, Italy; Interdisciplinary Research Centre on Biomaterials - CRIB, Università di Napoli Federico II, P.le Tecchio, 80, Napoli, Italy; Consorzio Interuniversitario INBB: Laboratorio Nazionale Interferenti Endocrini, Via Pietro Castellino 111, Napoli, Italy.
2
Consorzio Interuniversitario INBB: Laboratorio Nazionale Interferenti Endocrini, Via Pietro Castellino 111, Napoli, Italy; Dipartimento di Scienze Biologiche ed Ambientali, Università di Messina, Piazza Pugliatti 1, Messina, Italy.
3
Consorzio Interuniversitario INBB: Laboratorio Nazionale Interferenti Endocrini, Via Pietro Castellino 111, Napoli, Italy; Istituto di Bioscienze e Biorisorse - CNR, Via Pietro Castellino 111, Napoli, Italy.
4
Consorzio Interuniversitario INBB: Laboratorio Nazionale Interferenti Endocrini, Via Pietro Castellino 111, Napoli, Italy.
5
Dipartimento di Farmacia, Università di Napoli Federico II, Via D. Montesano 49, Napoli, Italy.
6
Consorzio Interuniversitario INBB: Laboratorio Nazionale Interferenti Endocrini, Via Pietro Castellino 111, Napoli, Italy; Dipartimento di Scienze del Farmaco e Prodotti per la Salute, Università di Messina, Piazza Pugliatti 1, Messina, Italy.
7
Dipartimento di Farmacia, Università di Napoli Federico II, Via D. Montesano 49, Napoli, Italy; Interdisciplinary Research Centre on Biomaterials - CRIB, Università di Napoli Federico II, P.le Tecchio, 80, Napoli, Italy; Consorzio Interuniversitario INBB: Laboratorio Nazionale Interferenti Endocrini, Via Pietro Castellino 111, Napoli, Italy. Electronic address: mabiondi@unina.it.

Abstract

The pharmacological potential of curcumin (CURC) is severely restricted because of its low water solubility/absorption, short half-life and poor bioavailability. To overcome these issues, CURC-loaded nanoparticles (NPs) were produced by a double emulsion technique. In particular, NPs were made up of an amphiphilic blend of poloxamers and PLGA to confer stealth properties to the NPs to take advantage of the enhanced permeability and retention (EPR) effect. Different surface properties of NPs made up of bare PLGA and PLGA/poloxamer blend were confirmed by the different interactions of these NPs with serum proteins and also by their ability to be internalized by mesothelioma cell line. The uptake of PLGA/poloxamer NPs induces a persistent block in G0/G1 phase of the cell cycle up to 72 h, thus overcoming the drug tolerance phenomenon, normally evidenced with free CURC.

KEYWORDS:

Curcumin; Mesothelioma; Nanoparticles; PLGA; Poloxamers; Stealth

PMID:
25794477
DOI:
10.1016/j.ejpb.2015.03.005
[Indexed for MEDLINE]

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