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Chem Biol. 2015 Mar 19;22(3):311-2. doi: 10.1016/j.chembiol.2015.03.004.

Fueling up skeletal muscle to reduce obesity: A TrkB story.

Author information

1
Divisions of Molecular Medicine and Cardiology, Departments of Anesthesiology and Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
2
Divisions of Molecular Medicine and Cardiology, Departments of Anesthesiology and Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: hcai@mednet.ucla.edu.

Abstract

Targeting TrkB signaling could represent a good therapeutic strategy to prevent obesity. In this issue of Chemistry & Biology, Chan et al. report the efficacy of 7,8-DHT, a TrkB agonist, in preventing obesity in female mice. The underlying molecular mechanisms behind this activity seem to involve increased energy expenditure in skeletal muscle.

PMID:
25794433
PMCID:
PMC4817994
DOI:
10.1016/j.chembiol.2015.03.004
[Indexed for MEDLINE]
Free PMC Article

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