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PLoS One. 2015 Mar 20;10(3):e0120704. doi: 10.1371/journal.pone.0120704. eCollection 2015.

Surface vulnerability of cerebral cortex to major depressive disorder.

Author information

1
Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Radiology and BRIC, University of North Carolina, Chapel Hill, North Carolina, United States of America.
2
Department of Radiology and BRIC, University of North Carolina, Chapel Hill, North Carolina, United States of America.
3
Suicide Research and Prevention Center, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Palo Alto University, Palo Alto, California, United States of America.
4
Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
5
The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.
6
Huashan Hospital, Fudan University, Shanghai, China.
7
Department of Radiology and BRIC, University of North Carolina, Chapel Hill, North Carolina, United States of America; Department of Brain and Cognitive Engineering, Korea University, Seoul, Republic of Korea.

Abstract

Major depressive disorder (MDD) is accompanied by atypical brain structure. This study first presents the alterations in the cortical surface of patients with MDD using multidimensional structural patterns that reflect different neurodevelopment. Sixteen first-episode, untreated patients with MDD and 16 matched healthy controls underwent a magnetic resonance imaging (MRI) scan. The cortical maps of thickness, surface area, and gyrification were examined using the surface-based morphometry (SBM) approach. Increase of cortical thickness was observed in the right posterior cingulate region and the parietal cortex involving the bilateral inferior, left superior parietal and right paracentral regions, while decreased thickness was noted in the parietal cortex including bilateral pars opercularis and left precentral region, as well as the left rostral-middle frontal regions in patients with MDD. Likewise, increased or decreased surface area was found in five sub-regions of the cingulate gyrus, parietal and frontal cortices (e.g., bilateral inferior parietal and superior frontal regions). In addition, MDD patients exhibited a significant hypergyrification in the right precentral and supramarginal region. This integrated structural assessment of cortical surface suggests that MDD patients have cortical alterations of the frontal, parietal and cingulate regions, indicating a vulnerability to MDD during earlier neurodevelopmental process.

PMID:
25793287
PMCID:
PMC4368815
DOI:
10.1371/journal.pone.0120704
[Indexed for MEDLINE]
Free PMC Article

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