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Imaging Sci Dent. 2015 Mar;45(1):7-13. doi: 10.5624/isd.2015.45.1.7. Epub 2015 Mar 13.

Volumetric quantification of bone-implant contact using micro-computed tomography analysis based on region-based segmentation.

Author information

1
Interdisciplinary Program in Radiation, Applied Life Science Major, College of Medicine, BK21, and Dental Research Institute, Seoul National University, Seoul, Korea.
2
Department of Oral and Maxillofacial Radiology, BK21, and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
3
Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.

Abstract

PURPOSE:

We have developed a new method of segmenting the areas of absorbable implants and bone using region-based segmentation of micro-computed tomography (micro-CT) images, which allowed us to quantify volumetric bone-implant contact (VBIC) and volumetric absorption (VA).

MATERIALS AND METHODS:

The simple threshold technique generally used in micro-CT analysis cannot be used to segment the areas of absorbable implants and bone. Instead, a region-based segmentation method, a region-labeling method, and subsequent morphological operations were successively applied to micro-CT images. The three-dimensional VBIC and VA of the absorbable implant were then calculated over the entire volume of the implant. Two-dimensional (2D) bone-implant contact (BIC) and bone area (BA) were also measured based on the conventional histomorphometric method.

RESULTS:

VA and VBIC increased significantly with as the healing period increased (p<0.05). VBIC values were significantly correlated with VA values (p<0.05) and with 2D BIC values (p<0.05).

CONCLUSION:

It is possible to quantify VBIC and VA for absorbable implants using micro-CT analysis using a region-based segmentation method.

KEYWORDS:

Absorbable Implants; Computer-Assisted Image Processing; Osseointegration; X-Ray Microtomography

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