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Anesth Pain Med. 2015 Feb 24;5(1):e23923. doi: 10.5812/aapm.23923. eCollection 2015 Feb.

Intravenous hypnotic regimens in patients with liver disease; a review article.

Author information

1
Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2
Department of Anesthesiology, Iran University of Medical Sciences, Tehran, Iran.
3
Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
4
Students' Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
5
Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Abstract

CONTEXT:

The liver as an important organ in the body has many essential functions in physiological processes. One of the major activities of liver is drug metabolism. Hepatic dysfunction affecting hepatic physiological activities, especially drug metabolism can cause many problems during anesthesia and administration of different drugs to patients.

EVIDENCE ACQUISITION:

Studies on hepatic disorders and hypnotic anesthetics prescribed in hepatic disorders were included in this review. For this purpose, reliable databases were used.

RESULTS:

Anesthesia should be performed with caution in patients with hepatic dysfunction and drugs with long half-life should be avoided in these patients.

CONCLUSIONS:

A review of the literature on the use of hypnotic drugs in patients with liver dysfunction showed that some hypnotic drugs used during anesthesia could be safely used in patients with impaired liver function. In these patients, certain drugs should be used with caution.

KEYWORDS:

Anesthesia; Hypnotics Drugs; Liver Disease

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