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In Vivo. 2015 Mar-Apr;29(2):207-15.

No changes in cerebral microcirculatory parameters in rat during local cortex exposure to microwaves.

Author information

1
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan Department of Environmental Health, National Institute of Public Health, Saitama, Japan bdxmsd@yahoo.co.jp.
2
Department of Environmental Health, National Institute of Public Health, Saitama, Japan.
3
Department of Computer Science and Engineering, Nagoya Institute of Technology, Aichi, Japan.
4
Department of Electrical and Electronics Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.
5
Department of Electrical and Electronics Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan Electromagnetic Compatibility Laboratory, Applied Electromagnetic Research Institute, National Institute of Information and Communications Technology, Tokyo, Japan.
6
Electromagnetic Compatibility Laboratory, Applied Electromagnetic Research Institute, National Institute of Information and Communications Technology, Tokyo, Japan.
7
Department of Electrical and Electronic Engineering, Tokyo Metropolitan University, Tokyo, Japan.
8
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
9
Department of Environmental Health, National Institute of Public Health, Saitama, Japan Japan EMF Information Center, Tokyo, Japan.

Abstract

The aim of this study was to determine whether cerebral microcirculatory parameters in rats were modified during local cortex exposure to a radiofrequency electromagnetic field (RF) under non-thermal conditions. The cortex tissue targeted was locally exposed to 1439 MHz RF using a figure-8 loop antenna at an averaged specific absorption rate of 2.0 W/kg in the target area for 50 min. Three microcirculatory parameters related to cerebral inflammation were measured by the cranial window method in real-time under RF exposure. No extravasation of intravenously injected fluorescent dye was observed during RF exposure. There was no significant difference either in pial venule blood flow velocity or diameter between exposed and sham-exposed rats. Histological evaluation for the brain immediately after RF exposure did not reveal any serum albumin leakage sites or degenerate neurons. These findings suggest that no dynamic changes occurred in cerebral microcirculation even during local cortex exposure under these conditions.

KEYWORDS:

Radiofrequency electromagnetic field; blood–brain barrier; hemodynamics; local exposure; microcirculation

PMID:
25792647
[Indexed for MEDLINE]

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