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Drug Chem Toxicol. 2016;39(1):48-52. doi: 10.3109/01480545.2015.1020546. Epub 2015 Mar 20.

Genoprotective and hepatoprotective effects of Guarana (Paullinia cupana Mart. var. sorbilis) on CCl4-induced liver damage in rats.

Author information

1
a Pharmacology Postgraduate Program .
2
b Pharmaceutical Sciences Postgraduate Program , and.
3
c Department of Clinical and Toxicological Analysis, Laboratory of Clinical Biochemistry , Health Sciences Center, Universidade Federal de Santa Maria , Santa Maria , RS , Brazil , and.
4
d Universidade Aberta da Terceira Idade, Universidade do Estado do Amazonas , Manaus , Amazonas , Brazil.

Abstract

CONTEXT:

Several biological effects of Paullinia cupana (guarana) have been demonstrated, but little information is available on its effects on the liver.

OBJECTIVE:

The current study was designed to evaluate the hepatoprotective and genoprotective effects of powder seeds from guarana on CCl4-induced liver injury in rats.

MATERIALS AND METHODS:

Male Wistar rats were pretreated with guarana powder (100, 300 and 600 mg/kg) or silymarin 100 mg/kg daily for 14 days before treatment with a single dose of CCl4 (50% CCl4, 1 mL/kg, intraperitoneally).

RESULTS:

The treatment with CCl4 significantly increased the serum activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). In addition, CCl4 increased the DNA damage index in hepatocytes. Guarana in all concentrations was effective in decreasing the ALT and AST activities when compared with the CCl4-treated group. The treatment with guarana decreased DNA damage index when compared with the CCl4-treated group. In addition, the DNA damage index showed a significant positive correlation with AST and ALT.

DISCUSSION AND CONCLUSION:

These results indicate that the guarana has hepatoprotective activity and prevents the DNA strand breakage in the CCl4-induced liver damage in rats.

KEYWORDS:

Genoprotection; Paullinia cupanna; liver; medicinal plants

PMID:
25791997
DOI:
10.3109/01480545.2015.1020546
[Indexed for MEDLINE]

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