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Br J Cancer. 2015 Apr 28;112(9):1585-93. doi: 10.1038/bjc.2015.90. Epub 2015 Mar 19.

Human papillomavirus DNA in men who have sex with men: type-specific prevalence, risk factors and implications for vaccination strategies.

Author information

1
Research Department of Infection and Population Health, University College London, London WC1E 6JB, UK.
2
1] Research Department of Infection and Population Health, University College London, London WC1E 6JB, UK [2] The Mortimer Market Centre, Central and North West London NHS Foundation Trust, London WC1E 6JB, UK.
3
Virus Reference Department, Public Health England, 61 Colindale Avenue, London NW9 5EQ, UK.
4
HIV/STI Department, Centre for Communicable Disease Surveillance and Control (CIDSC), Public Health England, 61 Colindale Avenue London, NW9 5EQ, UK.
5
1] Modelling and Economics Unit, Public Health England, 61 Colindale Avenue, London NW9 5EQ, UK [2] Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
6
Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.

Abstract

BACKGROUND:

Human papillomavirus (HPV) vaccination of girls will have relatively little effect on HPV-related disease in men who have sex with men (MSM). We determined HPV prevalence and risk factors in MSM to inform the potential effectiveness of vaccinating MSM.

METHODS:

Cross-sectional study of 522 MSM aged 18-40 attending a London sexual health clinic who completed a computer-assisted self-interview. Urine and two swabs (anal and penile/scrotal/perianal) were collected and tested using an in-house Luminex-based HPV genotyping system.

RESULTS:

Prevalence of DNA of the vaccine-preventable HPV types in ano-genital specimens of men was 87/511 (17.0%), 166/511 (32.5%) and 232/511 (45.4%) for the bivalent (HPV16/18), quadrivalent (HPV6/11/16/18) and nonavalent (HPV6/11/16/18/31/33/45/52/58) vaccine types, respectively. A total of 25.1% had one of the quadrivalent types, and 7.4% had 2+ types. Median age at first anal sex was 19 (IQR 17-23) and at first clinic attendance was 24 (IQR 20-27). The increase in the odds of any HPV infection per year of age was 4.7% (95% CI 1.2-8.4).

CONCLUSIONS:

On the basis of the current infection status, most MSM, even among a high-risk population attending a sexual health clinic, are not currently infected with the vaccine-type HPV. A targeted vaccination strategy for MSM in the UK could have substantial benefits.

PMID:
25791874
PMCID:
PMC4453685
DOI:
10.1038/bjc.2015.90
[Indexed for MEDLINE]
Free PMC Article

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