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Am J Ophthalmol. 2015 Jun;159(6):1123-1131.e1. doi: 10.1016/j.ajo.2015.03.005. Epub 2015 Mar 17.

Luminal and stromal areas of choroid determined by binarization method of optical coherence tomographic images.

Author information

1
Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
2
Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. Electronic address: tsakamot@m3.kufm.kagoshima-u.ac.jp.
3
Department of Ophthalmology, Kyushu University Graduate School of Medicine, Fukuoka, Japan.

Abstract

PURPOSE:

To determine the proportion of luminal and stromal areas of normal choroids in the optical coherence tomographic (OCT) images obtained by enhanced depth imaging (EDI)-OCT.

DESIGN:

A prospective, masked, observational cross-sectional study.

METHODS:

setting: This study was performed at the Kagoshima University Hospital, Japan.

STUDY POPULATION:

One hundred and eighty right eyes of 180 healthy volunteers (106 women; mean age of 55.9 years) without ocular pathology. observational procedures: The EDI-OCT images of the posterior choroid 7500 μm from the optic disc in the horizontal plane were converted to binary images. The total cross-sectional choroidal area, luminal area, and stromal area of the choroid were measured.

MAIN OUTCOME MEASURES:

Correlations between clinical factors and each choroidal structure and ratio of luminal/stromal areas were determined. The correlations of each choroidal structure and the age, sex, axial length (AL), and refractive errors were calculated.

RESULTS:

The mean total cross-sectional choroidal area was 1.84 mm(2) (luminal area 1.21 mm(2) and stromal area 0.63 mm(2)). Multivariate analysis (standardized partial regression coefficient) showed that age (-0.723, P < .001) was significantly correlated with the reduced area of the choroid, and the correlation was greater than that for the AL (-0.408, P < .001). The ratio of luminal/stromal area was significantly reduced in eyes with longer ALs (-0.531, P < .001), and the strength of the correlation was greater than that of age (-0.389, P < .001).

CONCLUSIONS:

Although both the luminal and the stromal areas decrease with increasing age and with longer ALs, the degree of decrease and areas affected were not the same.

PMID:
25790737
DOI:
10.1016/j.ajo.2015.03.005
[Indexed for MEDLINE]

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