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PLoS One. 2015 Mar 19;10(3):e0119713. doi: 10.1371/journal.pone.0119713. eCollection 2015.

Evaluation of shear wave velocity and human bone morphogenetic protein-7 for the diagnosis of diabetic kidney disease.

Author information

1
Department of Ultrasound, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
2
Department of Nephrology, Shanghai Jiaotong University Affiliated First People's Hospital, Shanghai, China.
3
Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
4
Department of Public Health Epidemiology of the Medical College of Qingdao University, Qingdao, Shandong, China.

Abstract

PURPOSE:

The aim of this study was to determine the diagnostic values of kidney shear wave velocity (SWV) and bone morphogenetic protein-7 (BMP-7), and their correlation in the diagnosis of early diabetic kidney disease.

METHODS:

A total of 150 patients with type 2 diabetes mellitus were divided into three equal groups based on the urinary albumin-creatinine ratio (ACR): normal albuminuria (normo- group, ACR < 30 mg/g creatinine, n = 50), microalbuminuria (micro- group, 30 ≤ ACR < 300 mg/g creatinine, n = 50), and macroalbuminuria (macro- group, ACR ≥ 300 mg/g creatinine and estimated glomerular filtration rate (eGFR) ≥30 ml/min/1.73 m2, n = 50). Fifty healthy volunteers were recruited to serve as controls (control group). The levels of serum BMP-7 were detected, and virtual touch tissue quantification was used to detect the renal SWV value in all study subjects. Correlations between groups as well as SWV and BMP-7 were analyzed.

RESULTS:

Serum BMP-7 and SWV were significantly and progressively decreased and increased, respectively, during the development of renal disease, from the normo- to the micro- and to the macro- groups (all P < 0.01 between each other for BMP-7 and SWV). Moreover, no significant differences between the normo- and control groups were observed for either BMP-7 or SWV (both P > 0.05). In addition, a significant correlation was found between SWV and BMP-7, with a coefficient of -0.569 (P < 0.05).

CONCLUSION:

The determination of SWV together with serum BMP-7 may play an important role in the diagnosis of diabetic kidney disease.

PMID:
25790348
PMCID:
PMC4366104
DOI:
10.1371/journal.pone.0119713
[Indexed for MEDLINE]
Free PMC Article

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