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PLoS One. 2015 Mar 19;10(3):e0119713. doi: 10.1371/journal.pone.0119713. eCollection 2015.

Evaluation of shear wave velocity and human bone morphogenetic protein-7 for the diagnosis of diabetic kidney disease.

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Department of Ultrasound, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Department of Nephrology, Shanghai Jiaotong University Affiliated First People's Hospital, Shanghai, China.
Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Department of Public Health Epidemiology of the Medical College of Qingdao University, Qingdao, Shandong, China.



The aim of this study was to determine the diagnostic values of kidney shear wave velocity (SWV) and bone morphogenetic protein-7 (BMP-7), and their correlation in the diagnosis of early diabetic kidney disease.


A total of 150 patients with type 2 diabetes mellitus were divided into three equal groups based on the urinary albumin-creatinine ratio (ACR): normal albuminuria (normo- group, ACR < 30 mg/g creatinine, n = 50), microalbuminuria (micro- group, 30 ≤ ACR < 300 mg/g creatinine, n = 50), and macroalbuminuria (macro- group, ACR ≥ 300 mg/g creatinine and estimated glomerular filtration rate (eGFR) ≥30 ml/min/1.73 m2, n = 50). Fifty healthy volunteers were recruited to serve as controls (control group). The levels of serum BMP-7 were detected, and virtual touch tissue quantification was used to detect the renal SWV value in all study subjects. Correlations between groups as well as SWV and BMP-7 were analyzed.


Serum BMP-7 and SWV were significantly and progressively decreased and increased, respectively, during the development of renal disease, from the normo- to the micro- and to the macro- groups (all P < 0.01 between each other for BMP-7 and SWV). Moreover, no significant differences between the normo- and control groups were observed for either BMP-7 or SWV (both P > 0.05). In addition, a significant correlation was found between SWV and BMP-7, with a coefficient of -0.569 (P < 0.05).


The determination of SWV together with serum BMP-7 may play an important role in the diagnosis of diabetic kidney disease.

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