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Circulation. 2015 May 19;131(20):1748-54. doi: 10.1161/CIRCULATIONAHA.114.014335. Epub 2015 Mar 18.

Coronary artery bypass grafting in patients 50 years or younger: a Swedish nationwide cohort study.

Author information

1
From Department of Cardiothoracic Surgery and Anesthesiology, Karolinska University Hospital, Stockholm, Sweden (M.D., T.I., U.S.); Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (M.D., T.I., U.S.); Department of Emergency Medicine, Karolinska University Hospital, Stockholm, Sweden (M.J.H.); and Department of Internal Medicine, Karolinska Institutet, Stockholm, Sweden (M.J.H.).
2
From Department of Cardiothoracic Surgery and Anesthesiology, Karolinska University Hospital, Stockholm, Sweden (M.D., T.I., U.S.); Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (M.D., T.I., U.S.); Department of Emergency Medicine, Karolinska University Hospital, Stockholm, Sweden (M.J.H.); and Department of Internal Medicine, Karolinska Institutet, Stockholm, Sweden (M.J.H.). Ulrik.Sartipy@karolinska.se.

Abstract

BACKGROUND:

There are limited data regarding long-term results after coronary artery bypass grafting (CABG) in young adults. We performed a nationwide population-based cohort study to analyze long-term survival, major adverse cardiovascular events, and factors associated with elevated risk in young adults undergoing CABG.

METHODS AND RESULTS:

We included all adult patients ≤50 years of age who underwent primary isolated CABG in Sweden between 1997 and 2013 from the Swedish Web System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies (SWEDEHEART) register. Patient data were linked from national Swedish health data registers to create a study database. We identified 4086 young adults with a mean age of 46 years and 18% women. During a median follow-up time of 10.9 years (interquartile range, 6.4-14.1) 490 (12%) patients died. Survival at 5, 10, and 15 years was 96% (95% CI, 95-96), 90% (95% CI, 89-91), and 82% (95%CI, 80-83), respectively, which was significantly better in comparison with patients aged 51 to 70 years and >70 years who underwent CABG during the same period. The cumulative incidence of death or a major adverse cardiovascular event during 17 years after CABG was mainly driven by myocardial infarction or the need for repeat revascularization. The most important risk factors for all-cause mortality were chronic kidney disease, reduced left ventricular ejection fraction, peripheral vascular disease, or chronic obstructive pulmonary disease.

CONCLUSIONS:

Long-term survival and freedom from major cardiovascular events after CABG was better in young adults than in older patients. Factors significantly associated with an elevated long-term risk of death or adverse outcome were similar to well-known risk factors for older age groups following CABG.

CLINICAL TRIAL REGISTRATION:

URL: http://www.clinicaltrials.gov. Unique identifier: NCT02276950.

KEYWORDS:

cohort studies; coronary artery bypass; coronary artery disease; outcome assessment (health care); young adult

[Indexed for MEDLINE]

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