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Angew Chem Int Ed Engl. 2015 May 11;54(20):5933-8. doi: 10.1002/anie.201412204. Epub 2015 Mar 18.

A synthetic erectile optogenetic stimulator enabling blue-light-inducible penile erection.

Author information

1
Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH-4058 Basel (Switzerland).

Abstract

Precise spatiotemporal control of physiological processes by optogenetic devices inspired by synthetic biology may provide novel treatment opportunities for gene- and cell-based therapies. An erectile optogenetic stimulator (EROS), a synthetic designer guanylate cyclase producing a blue-light-inducible surge of the second messenger cyclic guanosine monophosphate (cGMP) in mammalian cells, enabled blue-light-dependent penile erection associated with occasional ejaculation after illumination of EROS-transfected corpus cavernosum in male rats. Photostimulated short-circuiting of complex psychological, neural, vascular, and endocrine factors to stimulate penile erection in the absence of sexual arousal may foster novel advances in the treatment of erectile dysfunction.

KEYWORDS:

erectile dysfunction; gene expression; gene technology; optogenetic therapy; synthetic biology

PMID:
25788334
DOI:
10.1002/anie.201412204
[Indexed for MEDLINE]

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