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High Blood Press Cardiovasc Prev. 2015 Sep;22(3):203-13. doi: 10.1007/s40292-015-0081-8. Epub 2015 Mar 19.

Nutraceuticals and Blood Pressure Control: Results from Clinical Trials and Meta-Analyses.

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Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy,


Beyond the well-known effects on blood pressure (BP) of the dietary approaches to stop hypertension (DASH) and the Mediterranean diets, a large number of studies has investigated the possible BP lowering effect of different dietary supplements and nutraceuticals, the most part of them being antioxidant agents with a high tolerability and safety profile. In particular relatively large body of evidence support the use of potassium, L-arginine, vitamin C, cocoa flavonoids, beetroot juice, coenzyme Q10, controlled-release melatonin, and aged garlic extract. However there is a need for data about the long-term safety of a large part of the above discussed products. Moreover further clinical research is advisable to identify between the available active nutraceuticals those with the best cost-effectiveness and risk-benefit ratio for a large use in general population with low-added cardiovascular risk related to uncomplicated hypertension.

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