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Tumour Biol. 2015 Aug;36(8):6173-9. doi: 10.1007/s13277-015-3301-x. Epub 2015 Mar 19.

Squalene epoxidase (SQLE) promotes the growth and migration of the hepatocellular carcinoma cells.

Author information

1
Department of General Surgery, Zhongda Hospital, School of Medicine, Southeast University, 87 Dingjiaqiao Rd, Nanjin, 210009, Jiangsu Province, China.

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignancies with a poor response to chemotherapy. It is very important to identify novel therapeutic targets. Squalene epoxidase (SQLE), one of the rate-limiting enzymes in the cholesterol biosynthesis, recently has been found to be involved in the tumorigenesis. However, its expression profile and function in the progression of HCC remain largely unknown. Here, we found that the expression of SQLE was upregulated in the HCC tissues. Moreover, overexpression of SQLE in HCC cells promoted cell proliferation and migration, while downregulation of SQLE inhibited the tumorigenicity of HCC cells in vitro and in vivo. Mechanistically, SQLE positively regulated the ERK signaling. Taken together, our study suggests that SQLE is a promising therapeutic target in HCC.

PMID:
25787749
DOI:
10.1007/s13277-015-3301-x
[Indexed for MEDLINE]

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