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Hippocampus. 2015 Jun;25(6):744-52. doi: 10.1002/hipo.22454. Epub 2015 Apr 15.

Current questions on space and time encoding.

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Center for Systems Neuroscience, Center for Memory and Brain, Department of Psychological and Brain Sciences and Graduate Program for Neuroscience, Boston University, Boston, Massachusetts.


The Nobel Prize in Physiology or Medicine 2014 celebrated the groundbreaking findings on place cells and grid cells by John O'Keefe and May-Britt Moser and Edvard Moser. These findings provided an essential foothold for understanding the cognitive encoding of space and time in episodic memory function. This foothold provides a closer view of a broad new world of important research questions raised by the phenomena of place cells and grid cells. These questions concern the mechanisms of generation of place and grid cell firing, including sensory influences, circuit dynamics and intrinsic properties. Similar questions concern the generation of time cells. In addition, questions concern the functional role of place cells, grid cells and time cells in mediating goal-directed behavior and episodic memory function.


entorhinal cortex; grid cells; place cells; rat

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