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Immunity. 2015 Mar 17;42(3):403-5. doi: 10.1016/j.immuni.2015.02.019.

CNS injury: IL-33 sounds the alarm.

Author information

1
FM Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
2
FM Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: clifford.woolf@childrens.harvard.edu.

Abstract

Central nervous system trauma induces marked inflammation that has beneficial and deleterious consequences. In a recent issue of Neuron, Gadani et al. (2015) show that injured spinal cord releases the alarmin IL-33 to drive chemokines that recruit monocytes and promote recovery.

PMID:
25786172
DOI:
10.1016/j.immuni.2015.02.019
[Indexed for MEDLINE]
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