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PLoS One. 2015 Mar 18;10(3):e0121744. doi: 10.1371/journal.pone.0121744. eCollection 2015.

STEP levels are unchanged in pre-frontal cortex and associative striatum in post-mortem human brain samples from subjects with schizophrenia, bipolar disorder and major depressive disorder.

Author information

1
Pfizer Research & Development, Cambridge, MA, United States of America.
2
Arbor Analytics, Ann Arbor, MI, United States of America.

Abstract

Increased protein levels of striatal-enriched tyrosine phosphatase (STEP) have recently been reported in postmortem schizophrenic cortex. The present study sought to replicate this finding in a separate cohort of postmortem samples and to extend observations to striatum, including subjects with bipolar disorder and major depressive disorder in the analysis. No statistically significant changes between disease and control subjects were found in STEP mRNA or protein levels in dorsolateral prefrontal cortex or associative striatum. Although samples were matched for several covariates, postmortem interval correlated negatively with STEP protein levels, emphasizing the importance of including these analyses in postmortem studies.

PMID:
25786133
PMCID:
PMC4364624
DOI:
10.1371/journal.pone.0121744
[Indexed for MEDLINE]
Free PMC Article

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