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J Med Food. 2015 Jun;18(6):631-41. doi: 10.1089/jmf.2014.3292. Epub 2015 Mar 18.

The n-Butanol Fraction and Rutin from Tartary Buckwheat Improve Cognition and Memory in an In Vivo Model of Amyloid-β-Induced Alzheimer's Disease.

Author information

1
1Department of Food Science and Nutrition, Research Institute of Ecology for the Elderly, Pusan National University, Busan, Korea.
2
2Department of Integrative Plant Science, Chung-Ang University, Anseong, Korea.
3
3Department of Functional Crops, National Institute of Crop Science, Rural Development Administration, Miryang, Korea.

Abstract

This study examined the beneficial effects of the n-butanol fraction and rutin extracted from tartary buckwheat (TB) on learning and memory deficits in a mouse model of amyloid β (Aβ)-induced Alzheimer's disease (AD). Learning and memory were assessed using the T-maze, object recognition, and Morris water maze tests. Animals administered Aβ showed impaired cognition and memory, which were alleviated by oral administration of an n-butanol fraction and rutin extracted from TB. Similarly, Aβ-induced increases in nitric oxide formation and lipid peroxidation in the brain, liver, and kidneys were attenuated by treatment with n-butanol fraction and rutin from TB in addition to antioxidant effects observed in control (nonAβ-treated) animals. The results of the present study suggest that the n-butanol fraction and rutin extracted from TB are protective against and have possible therapeutic applications for the treatment of AD.

KEYWORDS:

Alzheimer's disease; amyloid β; memory; oxidative stress; rutin; tartary buckwheat

PMID:
25785882
DOI:
10.1089/jmf.2014.3292
[Indexed for MEDLINE]

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