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Nat Rev Mol Cell Biol. 2015 Apr;16(4):232-44. doi: 10.1038/nrm3966. Epub 2015 Mar 18.

Signalling scaffolds and local organization of cellular behaviour.

Author information

1
Howard Hughes Medical Institute and Department of Pharmacology, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA.

Abstract

Cellular responses to environmental cues involve the mobilization of GTPases, protein kinases and phosphoprotein phosphatases. The spatial organization of these signalling enzymes by scaffold proteins helps to guide the flow of molecular information. Allosteric modulation of scaffolded enzymes can alter their catalytic activity or sensitivity to second messengers in a manner that augments, insulates or terminates local cellular events. This Review examines the features of scaffold proteins and highlights examples of locally organized groups of signalling enzymes that drive essential physiological processes, including hormone action, heart rate, cell division, organelle movement and synaptic transmission.

PMID:
25785716
PMCID:
PMC4722875
DOI:
10.1038/nrm3966
[Indexed for MEDLINE]
Free PMC Article

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