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PLoS One. 2015 Mar 18;10(3):e0120409. doi: 10.1371/journal.pone.0120409. eCollection 2015.

Infarction of the corpus callosum: a retrospective clinical investigation.

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Neurology Department, Dalian Municipal Central Hospital affiliated to Dalian Medical University, 116033 Dalian, China.
Pathology Department, the Second Hospital of Dalian Medical University, 116027 Dalian, China.
Department of Clinical Epidemiology and Center of Evidence Based Medicine, the First Hospital of China Medical University, 110001 Shenyang, China.
Radiology Department, Dalian Municipal Central Hospital affiliated to Dalian Medical University, 116033 Dalian, China.
Neurology Department, Institute of Clinical Medicine, University of Eastern Finland, 70210 Kuopio, Finland.
Department of Cell Therapy, Fraunhofer Institute for Cell Therapy and Immunology, 04103 Leipzig, Germany; Translational Centre for Regenerative Medicine, 04103 Leipzig, Germany.



The aim of this study was to investigate patients with ischemic infarctions in the territory of the corpus callosum to advance our understanding of this rare stroke subtype by providing comprehensive descriptive and epidemiological data.


From January 1, 2010 to June 30, 2014, all cases of acute ischemic stroke diagnosed by clinical manifestation and diffusion weighted imaging in Dalian Municipal Central Hospital were investigated. The patients presenting with corpus callosum infarctions were selected and further allocated into genu and/or body and splenium infarction groups. Proportion, lesion patterns, clinical features, risk factors and etiology of corpus callosum infarction were analyzed.


Out of 1,629 cases, 59 patients (3.6%) with corpus callosum infarctions were identified by diffusion weighted imaging, including 7 patients who had ischemic lesions restricted to the corpus callosum territory. Thirty six patients had lesions in the splenium (61.0%). Corpus callosum infarction patients suffered from a broad spectrum of symptoms including weakness and/or numbness of the limbs, clumsy speech, and vertigo, which could not be explained by lesions in corpus callosum. A classical callosal disconnection syndrome was found in 2 out of all patients with corpus callosum infarctions. Statistical differences in the risk factor and infarct pattern between the genu and/or body group and splenium group were revealed.


Corpus callosum infarction and the callosal disconnection syndrome were generally rare. The most susceptible location of ischemic corpus callosum lesion was the splenium. Splenium infarctions were often associated with bilateral cerebral hemisphere involvement (46.2%). The genu and/or body infarctions were associated with atherosclerosis. The most common cause of corpus callosum infarction probably was embolism.

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