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Front Cell Neurosci. 2015 Mar 2;9:25. doi: 10.3389/fncel.2015.00025. eCollection 2015.

Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseases.

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Department of Pharmacological and Biomolecular Sciences, University of Milano Milano, Italy.
Department of Fundamental Neuroscience, University of Lausanne Lausanne, Switzerland.


Dopamine (DA) plays a major role in motor and cognitive functions as well as in reward processing by regulating glutamatergic inputs. In particular in the striatum the release of DA rapidly influences synaptic transmission modulating both AMPA and NMDA receptors. Several neurodegenerative and neuropsychiatric disorders, including Parkinson, Huntington and addiction-related diseases, manifest a dysregulation of glutamate and DA signaling. Here, we will focus our attention on the mechanisms underlying the modulation of the glutamatergic transmission by DA in striatal circuits.


AMPA receptors; Addiction; Dopamine; Huntington disease; NMDA receptor; Parkinson disease

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