Format

Send to

Choose Destination
Psychiatry Clin Neurosci. 2015 Aug;69(8):497-503. doi: 10.1111/pcn.12294. Epub 2015 Apr 21.

Risperidone long-acting injection and 1-year rehospitalization rate of schizophrenia patients: A retrospective cohort study.

Author information

1
Department of Psychiatry, E-Da Hospital, Kaohsiung, Taiwan.
2
Graduate Institute of Health Care Administration, I-Shou University, Kaohsiung, Taiwan.
3
Department of Quality and Safety, E-Da Hospital, Kaohsiung, Taiwan.
4
Department of Business Administration, National Sun Yat-Sen University, Kaohsiung, Taiwan.
5
School of Medicine, I-Shou University, Kaohsiung, Taiwan.

Abstract

AIMS:

We wanted to present a picture of patients with schizophrenia receiving risperidone long-acting injection (RLAI) treatment in a real-world setting.

METHODS:

This was a retrospective cohort study; 379 patients with schizophrenia were enrolled and treated with different kinds of antipsychotic agents at E-Da Hospital, and received a 12-month follow up. The patients were distributed into three groups: the all-oral antipsychotic, oral risperidone and RLAI groups. The antipsychotic agents and dosages they used were recorded. The rate of rehospitalization, length of hospital stay, emergency room visits and medical expenditures were assessed.

RESULTS:

The RLAI group had a significantly higher rate of hospitalization before enrolment (the all-oral antipsychotic group was 32.1%, the oral risperidone group, 35.9%, and the RLAI group, 88.4%, P < 0.0001). After a 1-year follow up, all three groups were similar in rehospitalization rates (the all-oral antipsychotic group was 28.9%, the oral risperidone group, 30.1%, and the RLAI group, 30.2%, P > 0.999), length of hospital stay and number of emergency room visits during follow up. The most commonly used oral antipsychotics were risperidone (0.5-7 mg/day), quetiapine (65-1200 mg/day), and olanzapine (2-25 mg/day).

CONCLUSIONS:

Using RLAI reduces the severity of disease in more difficult patients.

KEYWORDS:

antipsychotic agents; hospital emergency service; patient readmission; risperidone; schizophrenia

PMID:
25781185
DOI:
10.1111/pcn.12294
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center