Send to

Choose Destination
Cold Spring Harb Perspect Biol. 2015 Mar 16;7(4):a021840. doi: 10.1101/cshperspect.a021840.

Noninvasive functional and anatomical imaging of the human medial temporal lobe.

Author information

Department of Psychology, Stanford University, Stanford, California 94305-2130.
Department of Psychology, Stanford University, Stanford, California 94305-2130 Neurosciences Program, Stanford University, Stanford, California 94305-2130.


The ability to remember life's events, and to leverage memory to guide behavior, defines who we are and is critical for everyday functioning. The neural mechanisms supporting such mnemonic experiences are multiprocess and multinetwork in nature, which creates challenges for studying them in humans and animals. Advances in noninvasive neuroimaging techniques have enabled the investigation of how specific neural structures and networks contribute to human memory at its many cognitive and mechanistic levels. In this review, we discuss how functional and anatomical imaging has provided novel insights into the types of information represented in, and the computations performed by, specific medial temporal lobe (MTL) regions, and we consider how interactions between the MTL and other cortical and subcortical structures influence what we learn and remember. By leveraging imaging, researchers have markedly advanced understanding of how the MTL subserves declarative memory and enables navigation of our physical and mental worlds.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center