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Expert Rev Gastroenterol Hepatol. 2015 Jun;9(6):757-64. doi: 10.1586/17474124.2015.1026328. Epub 2015 Mar 16.

Familial colorectal cancer syndromes: an overview of clinical management.

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Colorectal Surgery Unit, Department of Surgery, The Royal Melbourne Hospital, Melbourne, VIC, Australia.


Familial colorectal cancer syndromes pose a complex challenge to the treating clinician. Once a syndrome is recognized, genetic testing is often required to confirm the clinical suspicion. Management from that point is usually based on disease-specific guideline recommendations targeting risk reduction for the patient and their relatives through surgery, surveillance and chemoprophylaxis. The aim of this paper is to provide an up-to-date summary of the most common familial syndromes and their medical and surgical management, with specific emphasis on evidence-based interventions that improve patient outcome, and to present the information in a manner that is easily readable and clinically relevant to the treating clinician.


Lynch; adenoma; colorectal cancer; familial; polyposis

[Indexed for MEDLINE]

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