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Mov Disord. 2015 May;30(6):850-4. doi: 10.1002/mds.26192. Epub 2015 Mar 17.

Genetic risk and age in Parkinson's disease: Continuum not stratum.

Author information

1
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
2
MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, Wales, UK.
3
Department of Clinical Neuroscience, UCL Institute of Neurology, London, England, UK.
4
Merck Research Laboratories, Cambridge, Massachusetts, USA.

Abstract

BACKGROUND:

Recent genomewide association study meta-analyses have identified 28 loci associated with risk of Parkinson's disease (PD). We sought to investigate whether these genetic risk factors are associated with PD age at onset.

METHODS:

Genetic risk scores from these loci were calculated for 6,249 cases. Linear regression tested associations between cumulative genetic risk and PD age at onset.

RESULTS:

Increasing genetic risk scores were associated with earlier age at onset (beta = -0.10, P = 2.92 × 10(-8) , adjusted r(2)  = 0.27). Single standard deviation increase in genetic risk score is associated with 37.44 d earlier age at onset. Highest genetic risk was found at 31 to 60 y, onset slightly below average age at onset (AAO).

CONCLUSIONS:

Common genetic risk factors have a small but consistent association with AAO in PD.

KEYWORDS:

Parkinson's disease; age at onset; genetics; statistics

PMID:
25778492
PMCID:
PMC5217457
DOI:
10.1002/mds.26192
[Indexed for MEDLINE]
Free PMC Article

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