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Neurosci Lett. 2015 Apr 23;593:24-8. doi: 10.1016/j.neulet.2015.03.019. Epub 2015 Mar 13.

Involvement of norepinephrine and serotonin system in antidepressant-like effects of oleoylethanolamide in the mice models of behavior despair.

Author information

1
College of Medicine, Yanbian University, Park street 977, Yanji 133002, Jilin, PR China. Electronic address: hlyu@ybu.edu.cn.
2
College of Medicine, Yanbian University, Park street 977, Yanji 133002, Jilin, PR China.
3
College of Pharmacy, Yanbian University, Park street 977, Yanji 133002, Jilin, PR China. Electronic address: zsquan@ybu.edu.cn.

Abstract

Oleoylethanolamide (OEA) is an endocannabinoid analogy that belongs to a family of endogenous acylethanolamides. Increasing evidence suggests that OEA may act as an endogenous neuroprotective factor and participate in the control of mental disorder-related behaviors. In the present study, we investigated the antidepressant- like potential of OEA in mice in comparison with clomipramine (Cp). 50 mice were randomly divided into 5 groups, and treated with a vehicle (0.3% methyl cellulose, 20 mL/kg, p.o.), OEA (2.5, 5-10mg/kg, p.o.), or Cp (10mg/kg, p.o.) for 7 days. The immobility was used to evaluate depressive-like behaviors in tail suspension test (TST) and forced swimming test (FST). ELISA detected changes in cerebral noradrenaline (NE) and serotonin (5-HT) levels. Likewise, in the drug-induced model of depression, OEA was given once daily at 10mg/kg (p.o.) for 7 consecutive days. Then, the mice received reserpine (4 mg/kg, i.p.) and the rectal temperature was measured at different time points. Consequently, head twitch behavior induced by intraperitoneal injection of 5-hydroxy-tryptophan (5-HTP; 300 mg/kg) were determined. The experimental data showed that OEA (2.5-10mg/kg) treatment significantly decreased the immobility as compared to the control group, and OEA (10mg/kg) treatment significantly increased 5-HTP-induced head twitch behavior and reversed reserpine-induced hypothermia and increased cerebral levels of NE and 5-HT. Thus, the antidepressant effects of OEA may be related to regulating central monoamine neurotransmitters.

KEYWORDS:

Antidepressant; Mice; Noradrenaline; Oleoylethanolamide; Serotonin

PMID:
25778418
DOI:
10.1016/j.neulet.2015.03.019
[Indexed for MEDLINE]

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