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Int J Dermatol. 2015 Jun;54(6):730-5. doi: 10.1111/ijd.12650. Epub 2015 Mar 16.

Clinical use of conditioned media of adipose tissue-derived stem cells in female pattern hair loss: a retrospective case series study.

Author information

  • 1Department of Dermatology, Dongguk University Ilsan Hospital, Goyang, South Korea.
  • 2Department of Dermatology, Seoul National University College of Medicine, Seoul, South Korea.
  • 3Cellpark Clinic, Seoul, South Korea.

Abstract

BACKGROUND:

Female pattern hair loss (FPHL) is a common disorder but presents severe psychosocial problems in many female patients. Adipose tissue-derived stem cells (ADSCs) and conditioned media of ADSCs (ADSC-CM) are reported to promote hair growth in vitro. However, there are no clinical reports on the treatment of alopecia using ADSC-CM.

OBJECTIVES:

This study evaluates our clinical experience in the use of ADSC-CM for the treatment of FPHL.

METHODS:

A retrospective, observational study of outcomes in 27 patients with FPHL treated with ADSC-CM was performed. To evaluate the efficacy of the treatment, patients' medical records and phototrichographic images were analyzed.

RESULTS:

The application of ADSC-CM showed efficacy in treating FPHL after 12 weeks of therapy. Hair density increased from 105.4 to 122.7 hairs/cm(2) (P < 0.001). Hair thickness increased from 57.5 μm to 64.0 μm (P < 0.001). None of the patients reported severe adverse reactions.

CONCLUSIONS:

The application of ADSC-CM is a potential treatment option for FPHL.

PMID:
25777970
DOI:
10.1111/ijd.12650
[PubMed - indexed for MEDLINE]
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