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J Photochem Photobiol B. 2015 May;146:10-7. doi: 10.1016/j.jphotobiol.2015.02.008. Epub 2015 Feb 25.

Antioxidant and anti-inflammatory activities of zinc oxide nanoparticles synthesized using Polygala tenuifolia root extract.

Author information

1
Department of Physiology, College of Korean Medicine, Dongguk University, Gyeongju, South Korea.
2
Department of Physiology, Daegu Haany University, Gyeongsan 712-702, South Korea.
3
Department of Life Chemistry, College of Natural Science, Catholic University of Daegu, Gyeongsan 712-702, South Korea.
4
Department of Physiology, College of Korean Medicine, Dongguk University, Gyeongju, South Korea; Korea Promotion Institute for Traditional Medicine Industry, Gyeongsan, Gyeongbuk 712-210, South Korea. Electronic address: heungmuk@dongguk.ac.kr.

Abstract

The exploitation of various plant materials for the green synthesis of nanoparticles is considered an eco-friendly technology because it does not involve toxic chemicals. In this study, zinc oxide nanoparticles (ZnO NPs) were synthesized using the root extract of Polygala tenuifolia. Synthesized ZnO NPs were characterized by UV-Vis spectroscopy, FTIR, TGA, TEM, SEM and EDX. Anti-inflammatory activity was investigated in LPS-stimulated RAW 264.7 macrophages, whereas antioxidant activity was examined using a DPPH free radical assay. ZnO NPs demonstrated moderate antioxidant activity by scavenging 45.47% DPPH at 1mg/mL and revealed excellent anti-inflammatory activity by dose-dependently suppressing both mRNA and protein expressions of iNOS, COX-2, IL-1β, IL-6 and TNF-α.

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