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Chin J Integr Med. 2015 May;21(5):332-8. doi: 10.1007/s11655-015-2160-z. Epub 2015 Mar 17.

An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial.

Author information

1
Department of Biostatistics and Epidemiology, Research Health Center, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

OBJECTIVE:

To investigate the effectiveness of curcumin, a natural polyphenolic compound with antioxidant and anti-inflammatory activities, on the frequency of symptoms of anxiety and depression in obese individuals.

METHODS:

In this double blind, cross-over trial, 30 obese subjects were randomized to receive either curcumin (1 g/day) or placebo for a period of 30 days. Following a wash-out interval of 2 weeks, each subject was crossed over to the alternative regimen for a further 30 days. Severity of anxiety and depression was assessed at baseline and at weeks 4, 6 and 10 of the trial using the Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) scales, respectively.

RESULTS:

Mean BAI score was found to be significantly reduced following curcumin therapy (P=0.03). However, curcumin supplementation did not exert any significant impact on BDI scores (P=0.7).

CONCLUSION:

Curcumin has a potential anti-anxiety effect in individuals with obesity.

PMID:
25776839
DOI:
10.1007/s11655-015-2160-z
[Indexed for MEDLINE]

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