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J Cutan Med Surg. 2015 Mar-Apr;19(2):109-14. doi: 10.2310/7750.2014.14038. Epub 2015 Mar 5.

Interleukin-17 antagonists in the treatment of psoriasis.

Author information

1
Department of Dermatology and Skin Care, Women's College Hospital, and Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON schandrakumar@qmed.ca.
2
Department of Dermatology and Skin Care, Women's College Hospital, and Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON.

Abstract

BACKGROUND:

Psoriasis is a chronic, immune-mediated inflammatory skin disorder of unknown etiology. Interleukin (IL)-17a, a key product of the recently identified Th17 cell subset, has been found to play a critical role in the immunopathogenesis of psoriasis. IL-17 antagonists are a new class of biological agent currently in development for psoriasis that selectively inhibit IL-17a activity.

OBJECTIVE:

This review aims to summarize the current efficacy data from phase II randomized controlled trials of the IL-17 antagonists brodalumab, ixekizumab, and secukinumab for the treatment of moderate to severe psoriasis.

CONCLUSION:

Patients treated with IL-17 antagonists achieved marked reduction in psoriasis disease severity as demonstrated by the Psoriasis Area and Severity Index (PASI) 75 response rates. A sizable proportion of patients treated with brodalumab and ixekizumab achieved unprecedented clinical clearance of their psoriasis (PASI > 90). These encouraging results demonstrate the efficacy of these agents and validate the pro-inflammatory role of IL-17 in the pathophysiology of psoriasis.

PMID:
25775627
DOI:
10.2310/7750.2014.14038
[Indexed for MEDLINE]

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