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World J Biol Psychiatry. 2015 Sep;16(6):387-397. doi: 10.3109/15622975.2015.1017605. Epub 2015 Mar 16.

Reduced auditory evoked gamma band response and cognitive processing deficits in first episode schizophrenia.

Author information

1
a Department of Psychiatry and Psychotherapy , Psychiatry Neuroimaging Branch (PNB), University Medical Center Hamburg-Eppendorf , Hamburg , Germany.
2
b Department of Psychiatry and Psychotherapy , University Medical Center Hamburg-Eppendorf , Hamburg , Germany.

Abstract

OBJECTIVES:

Gamma-band oscillations (e.g., the early auditory evoked gamma-band response, aeGBR) have been suggested to mediate cognitive and perceptual processes by driving the synchronization of local neuronal populations. Reduced aeGBR is a consistent finding in patients with schizophrenia and high-risk subjects, and has been proposed to represent an endophenotype for the illness. However, it is still unclear whether this reduction represents a deficit in sensory or cognitive processes, or a combination of the two. The present study investigated this question by manipulating the difficulty of an auditory reaction task in patients with first-episode schizophrenia and healthy controls.

METHODS:

A 64-channel EEG was recorded in 23 patients with first-episode schizophrenia and 22 healthy controls during two conditions of an auditory reaction task: an easy condition that merely required low-level vigilance, and a difficult condition that placed significant demands on attention and working memory.

RESULTS:

In contrast to healthy controls, patients failed to increase aeGBR power and phase-locking in the difficult condition. In patients, aeGBR power and phase-locking indices were associated with working memory deficits.

CONCLUSIONS:

The observed results confirm the applicability of aeGBR disturbances as a stable endophenotype of schizophrenia, and suggest a cognitive, rather than sensory, deficit at their origin.

KEYWORDS:

EEG; auditory; first episode; gamma; schizophrenia

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