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Can J Diabetes. 2015 Aug;39(4):266-72. doi: 10.1016/j.jcjd.2014.11.006. Epub 2015 Mar 13.

Depression and Risk for Diabetes: A Meta-Analysis.

Author information

1
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China.
2
Hangzhou Center for Disease Control and Prevention, Hangzhou, Zhejiang, China.
3
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China. Electronic address: lefangchina@yeah.net.

Abstract

OBJECTIVE:

Many studies have reported the relationship between depression and diabetes, but the results have been inconsistent. Our aim was to conduct a systematic review through meta-analysis to assess the association of depression with the risk for developing diabetes.

METHODS:

We retrieved the studies concerning depression and the risk for diabetes. Meta-analysis was applied to calculate the combined effect values and their 95% confidence intervals. The risk for publication bias was assessed by the Egger regression asymmetry test.

RESULTS:

As many as 33 articles were included in the meta-analysis, for a total of 2 411 641 participants. The pooled relative risk for diabetes was 1.41 (95% CI, 1.25-1.59) for depression, and the combined relative risk for type 2 diabetes mellitus was 1.32 (95% CI, 1.18-1.47).

CONCLUSIONS:

Depressed people have a 41% increased risk for developing diabetes mellitus and a 32% increased risk for developing type 2 diabetes. The mechanisms underlying this relationship are still unclear and need further research.

KEYWORDS:

depression; diabetes; diabète; dépression; facteurs de risque; meta-analysis; méta-analyse; risk factors

PMID:
25773933
DOI:
10.1016/j.jcjd.2014.11.006
[Indexed for MEDLINE]

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