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Ann N Y Acad Sci. 2015 Jul;1347:45-51. doi: 10.1111/nyas.12726. Epub 2015 Mar 13.

Angiopoietin-2: a multifaceted cytokine that functions in both angiogenesis and inflammation.

Scholz A1, Plate KH2,3,4,5, Reiss Y2,3,4,5.

Author information

1
Department of Pathology, Laboratory of Immunology and Vascular Biology, Stanford University School of Medicine, Stanford, California.
2
Edinger Institute/Institute of Neurology, Frankfurt University Medical School, Frankfurt, Germany.
3
German Center for Cardiovascular Research (DZHK), Frankfurt, Germany.
4
German Cancer Consortium (DKTK), Frankfurt, Germany.
5
German Cancer Research Center (DKFZ), Heidelberg, Germany.

Abstract

Angiogenesis and inflammation are two highly linked processes. In the last decade, several factors with dual function in both of these major pathways have been identified. This review focuses on angiopoietin-2 (Ang-2), an important proangiogenic factor that has more recently been implicated in mediating inflammatory processes as well. Ang-2 is upregulated in multiple inflammatory diseases and has been implicated in the direct control of inflammation-related signaling pathways. As a consequence of its multiple roles, designs for therapeutic targeting of Ang-2 should consider the dual function of this factor in regulating angiogenesis and inflammation.

KEYWORDS:

Ang-2; angiopoietin; inflammation; innate immune cell; myeloid cell

PMID:
25773744
DOI:
10.1111/nyas.12726
[Indexed for MEDLINE]

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