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Trends Genet. 2015 Apr;31(4):215-9. doi: 10.1016/j.tig.2015.02.007. Epub 2015 Mar 12.

Genes from scratch--the evolutionary fate of de novo genes.

Author information

1
Institut für Populationsgenetik, Vetmeduni, Veterinärplatz 1, 1210 Wien, Austria. Electronic address: Christian.schloetterer@vetmeduni.ac.at.

Abstract

Although considered an extremely unlikely event, many genes emerge from previously noncoding genomic regions. This review covers the entire life cycle of such de novo genes. Two competing hypotheses about the process of de novo gene birth are discussed as well as the high death rate of de novo genes. Despite the high death rate, some de novo genes are retained and remain functional, even in distantly related species, through their integration into gene networks. Further studies combining gene expression with ribosome profiling in multiple populations across different species will be instrumental for an improved understanding of the evolutionary processes operating on de novo genes.

KEYWORDS:

de novo genes; orphans; population genetics; transcription

PMID:
25773713
PMCID:
PMC4383367
DOI:
10.1016/j.tig.2015.02.007
[Indexed for MEDLINE]
Free PMC Article

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