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J Neuroimmunol. 2015 Mar 15;280:66-8. doi: 10.1016/j.jneuroim.2015.03.003. Epub 2015 Mar 5.

Epitopes of HERV-Wenv induce antigen-specific humoral immunity in multiple sclerosis patients.

Author information

1
Dipartimento di Scienze Biomediche, Sezione di Microbiologia e Virologia, Università di Sassari, Viale San Pietro 43b, 07100 Sassari, Italy. Electronic address: gmameli@uniss.it.
2
Dipartimento di Scienze Biomediche, Sezione di Microbiologia e Virologia, Università di Sassari, Viale San Pietro 43b, 07100 Sassari, Italy.
3
Centro Sclerosi Multipla, Dipartimento di Sanità Pubblica Medicina Clinica e Molecolare, Università di Cagliari, Via Is Guadazzonis 2, 09126 Cagliari, Italy.
4
Dipartimento di Scienze Biomediche, Sezione di Microbiologia e Virologia, Università di Sassari, Viale San Pietro 43b, 07100 Sassari, Italy. Electronic address: sechila@uniss.it.

Abstract

To verify the serological response mounted against antigenic peptides from HERV-Wenv protein, we analyzed 80 multiple sclerosis (MS) serum samples, 27 of which were re-analyzed after a 6-month follow-up IFN-β therapy, and 73 healthy controls. Indirect ELISAs were carried out to detect antibodies specific for all the synthetic peptides derived from HERV-Wenv. Two antigenic peptides, HERV-Wenv93-108 (31.25%, p<0.0001) and HERV-Wenv248-262 (15%, p=0.02), were highly recognized by MS patients' antibodies when compared to healthy subjects. Moreover, antibody titer against these two peptides slightly decreased after six months of IFN-β-based therapy.

KEYWORDS:

HERV-Wenv; Humoral response; IFN-β therapy

PMID:
25773158
DOI:
10.1016/j.jneuroim.2015.03.003
[Indexed for MEDLINE]

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